InterPro : IPR019802

Name  Glycoside hydrolase, family 4, conserved site Short Name  GlycHydrolase_4_CS
Type  Conserved_site Description  O-Glycosyl hydrolases () are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [, ]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site.Glycoside hydrolase family 4 comprises enzymes with several known activities; 6-phospho-beta-glucosidase (); 6-phospho-alpha-glucosidase (); alpha-galactosidase ().These enzymes require NAD and a divalent ion for their activity and are proteins of about 50 kDa; e.g. 6-phospho-alpha-glucosidase requires both NAD(H) and divalent metal (Mn2+, Fe2+, Co2+, or Ni2+) for activity []. The signature pattern is located to a conserved region located in the central section. This region does not contain residues directly shown to be important for the catalytic activity.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

1 Found In

Id Name Short Name Type
IPR001088 Glycoside hydrolase, family 4 Glyco_hydro_4 Family

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Henrissat B Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases. 1995 Proc Natl Acad Sci U S A 92 7090-4
Davies G Structures and mechanisms of glycosyl hydrolases. 1995 Structure 3 853-9
Thompson J The gene glvA of Bacillus subtilis 168 encodes a metal-requiring, NAD(H)-dependent 6-phospho-alpha-glucosidase. Assignment to family 4 of the glycosylhydrolase superfamily. 1998 J Biol Chem 273 27347-56

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)