InterPro : IPR019802

Name  Glycoside hydrolase, family 4, conserved site Short Name  GlycHydrolase_4_CS
Type  Conserved_site Description  O-Glycosyl hydrolases () are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [, ]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site.Glycoside hydrolase family 4 comprises enzymes with several known activities; 6-phospho-beta-glucosidase (); 6-phospho-alpha-glucosidase (); alpha-galactosidase ().These enzymes require NAD and a divalent ion for their activity and are proteins of about 50 kDa; e.g. 6-phospho-alpha-glucosidase requires both NAD(H) and divalent metal (Mn2+, Fe2+, Co2+, or Ni2+) for activity []. The signature pattern is located to a conserved region located in the central section. This region does not contain residues directly shown to be important for the catalytic activity.
 Feedback

Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

0 Contains

1 Found In

Id Name Short Name Type
IPR001088 Glycoside hydrolase, family 4 Glyco_hydro_4 Family

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Henrissat B Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases. 1995 Proc Natl Acad Sci U S A 92 7090-4
Davies G Structures and mechanisms of glycosyl hydrolases. 1995 Structure 3 853-9
Thompson J The gene glvA of Bacillus subtilis 168 encodes a metal-requiring, NAD(H)-dependent 6-phospho-alpha-glucosidase. Assignment to family 4 of the glycosylhydrolase superfamily. 1998 J Biol Chem 273 27347-56



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)