InterPro : IPR003560

Name  2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase Short Name  DHB_DH
Type  Family Description  The absence of free iron molecules in the surrounding environment triggers transcription of gene clusters that encode both siderophore-synthesis enzymes, and receptors that recognise iron-bound siderophores []. Classic examples are the enterobactin/enterochelin clusters found in Escherichia coliand Salmonella, although similar moieties in other pathogens have been identified. The enzymic machinery that produces vibrionectin in Vibrio choleraeis such a homologue [].EntA, a 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase enzyme, is the third enzyme in the biosynthesis of 2,3-dihydroxybenzoic acid (DHB) from chorismate in Escherichia coli. It converts isochorismate to DHB, used for the synthesis of iron chelator enterobactin. Bacillus subtilis possesses similar genes involved in siderophore biosynthesis []. Deletion studies involving EntA-mutants have shown that it is essential for virulence [].
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

2 Contains

Id Name Short Name Type
IPR016040 NAD(P)-binding domain NAD(P)-bd_dom Domain
IPR020904 Short-chain dehydrogenase/reductase, conserved site Sc_DH/Rdtase_CS Conserved_site

0 Found In

0 Parent Features

4 Publications

First Author Title Year Journal Volume Pages
Nahlik MS Nucleotide sequence and transcriptional organization of the Escherichia coli enterobactin biosynthesis cistrons entB and entA. 1989 J Bacteriol 171 784-90
Liu J Nucleotide sequence of a cluster of Escherichia coli enterobactin biosynthesis genes: identification of entA and purification of its product 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase. 1989 J Bacteriol 171 791-8
Wyckoff EE Cloning of a Vibrio cholerae vibriobactin gene cluster: identification of genes required for early steps in siderophore biosynthesis. 1997 J Bacteriol 179 7055-62
Rowland BM Sequence and genetic organization of a Bacillus subtilis operon encoding 2,3-dihydroxybenzoate biosynthetic enzymes. 1996 Gene 178 119-23



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)