InterPro : IPR000847

Name  Transcription regulator HTH, LysR Short Name  Tscrpt_reg_HTH_LysR
Type  Domain Description  Numerous bacterial transcription regulatory proteins bind DNA via a helix-turn-helix (HTH) motif. These proteins are very diverse, but for convenience may be grouped into subfamilies on the basis of sequence similarity. One such family, the lysR family, groups together a range of proteins, including ampR, catM, catR, cynR, cysB, gltC, iciA, ilvY, irgB, lysR, metR, mkaC, mleR, nahR, nhaR, nodD, nolR, oxyR, pssR, rbcR, syrM, tcbR, tfdS and trpI [, , , , ]. The majority of these proteins appear to be transcription activatorsand most are known to negatively regulate their own expression. All possess a potential HTH DNA-binding motif towards their N-termini.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



1 Child Features

Id Name Short Name Type
IPR003725 Molybdenum-binding protein, N-terminal ModE-bd_N Domain

0 Contains

6 Found In

Id Name Short Name Type
IPR012787 Pca transcription factor PcaQ TF_PcaQ Family
IPR020890 Transcription regulator HTH, HdfR Tscrpt_reg_HTH_HdfR Family
IPR011781 D-serine deaminase transcriptional activator DsdC Family
IPR017685 Transcription regulator ArgP Tscrpt_reg_ArgP Family
IPR017724 Aminoethylphosphonate utilisation-associated transcription regulator, LysR-type Tscrpt_reg_LysR Family
IPR017786 Transcription factor, choline sulphate-utilisation, putative TF_choline_sulphate-util_put Family

1 Parent Features

Id Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain

5 Publications

First Author Title Year Journal Volume Pages
Viale AM rbcR [correction of rcbR], a gene coding for a member of the LysR family of transcriptional regulators, is located upstream of the expressed set of ribulose 1,5-bisphosphate carboxylase/oxygenase genes in the photosynthetic bacterium Chromatium vinosum. 1991 J Bacteriol 173 5224-9
Sung YC The Escherichia coli K-12 cyn operon is positively regulated by a member of the lysR family. 1992 J Bacteriol 174 3645-50
Kondorosi E Identification of NolR, a negative transacting factor controlling the nod regulon in Rhizobium meliloti. 1991 J Mol Biol 222 885-96
Henikoff S A large family of bacterial activator proteins. 1988 Proc Natl Acad Sci U S A 85 6602-6
Thöny B iciA, an Escherichia coli gene encoding a specific inhibitor of chromosomal initiation of replication in vitro. 1991 Proc Natl Acad Sci U S A 88 4066-70

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)