InterPro : IPR020046

Name  5'-3' exonuclease, alpha-helical arch, N-terminal Short Name  5-3_exonucl_a-hlix_arch_N
Type  Domain Description  The N-terminal and internal 5'3'-exonuclease domains are commonly found together, and are most often associated with 5' to 3' nuclease activities. The XPG protein signatures () are never found outside the '53EXO' domains. The latter are found in more diverse proteins [, , ]. The number of amino acids that separate the two 53EXO domains, and the presence of accompanying motifs allow the diagnosis of several protein families.In the eubacterial type A DNA-polymerases, the N-terminal and internal domains are separated by a few amino acids, usually four. The pattern DNA_POLYMERASE_A () is always present towards the C terminus. Several eukaryotic structure-dependent endonucleases and exonucleases have the 53EXO domains separated by 24 to 27 amino acids, and the XPG protein signatures are always present. In several proteins from herpesviridae, the two 53EXO domains are separated by 50 to 120 amino acids. These proteins are implicated in the inhibition of the expression of the host genes. Eukaryotic DNA repair proteins with 600 to 700 amino acids between the 53_EXO domains all carry the XPG protein signatures. This entry represents the N-terminal resolvase-like domain, which has a 3-layer alpha/beta/alpha core structure and contains an alpha-helical arch [, ].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

3 Found In

Id Name Short Name Type
IPR002298 DNA polymerase A DNA_polymerase_A Family
IPR018320 DNA polymerase 1 DNA_polymerase_1 Family
IPR002421 5'-3' exonuclease, N-terminal 5-3_exonuclease_N Domain

1 Parent Features

Id Name Short Name Type
IPR029060 PIN domain-like PIN_domain-like Domain

5 Publications

First Author Title Year Journal Volume Pages
Smith TF The WD repeat: a common architecture for diverse functions. 1999 Trends Biochem Sci 24 181-5
Carr AM Evolutionary conservation of excision repair in Schizosaccharomyces pombe: evidence for a family of sequences related to the Saccharomyces cerevisiae RAD2 gene. 1993 Nucleic Acids Res 21 1345-9
Harrington JJ Functional domains within FEN-1 and RAD2 define a family of structure-specific endonucleases: implications for nucleotide excision repair. 1994 Genes Dev 8 1344-55
Eom SH Structure of Taq polymerase with DNA at the polymerase active site. 1996 Nature 382 278-81
Ceska TA A helical arch allowing single-stranded DNA to thread through T5 5'-exonuclease. 1996 Nature 382 90-3

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)