InterPro : IPR011304

Name  L-lactate dehydrogenase Short Name  L-lactate_DH
Type  Family Description  This entry represents the NAD-dependent L-lactate dehydrogenases from bacteria and eukaryotes. This enzyme functions as the final step in anaerobic glycolysis. Although lactate dehydrogenases have in some cases been mistaken for malate dehydrogenases due to the similarity of these two substrates and the apparent ease with which evolution can toggle these activities, critical residues have been identified []which can discriminate between the two activities.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

5 Contains

Id Name Short Name Type
IPR016040 NAD(P)-binding domain NAD(P)-bd_dom Domain
IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal Lactate_DH/Glyco_Ohase_4_C Domain
IPR001236 Lactate/malate dehydrogenase, N-terminal Lactate/malate_DH_N Domain
IPR022383 Lactate/malate dehydrogenase, C-terminal Lactate/malate_DH_C Domain
IPR018177 L-lactate dehydrogenase, active site L-lactate_DH_AS Active_site

0 Found In

1 Parent Features

Id Name Short Name Type
IPR001557 L-lactate/malate dehydrogenase L-lactate/malate_DH Family

1 Publications

First Author Title Year Journal Volume Pages
Hannenhalli SS Analysis and prediction of functional sub-types from protein sequence alignments. 2000 J Mol Biol 303 61-76

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)