InterPro : IPR022272

Name  Lipocalin family conserved site Short Name  Lipocalin_CS
Type  Conserved_site Description  The lipocalins are a diverse, interesting, yet poorly understood family of proteins composed, in the main, of extracellular ligand-binding proteinsdisplaying high specificity for small hydrophobic molecules []. Functionsof these proteins include transport of nutrients, control of cell regulation, pheromone transport, cryptic colouration, and the enzymatic synthesisof prostaglandins.The crystal structures of several lipocalins have been solved and show a novel 8-stranded anti-parallel beta-barrel fold well conserved within thefamily. Sequence similarity within the family is at a much lower level andwould seem to be restricted to conserved disulphides and 3 motifs, whichform a juxtaposed cluster that may act as a common cell surface receptorsite [, ]. By contrast, at the more variable end of the fold are found an internal ligand binding site and a putative surface for the formation of macromolecular complexes []. The anti-parallel beta-barrel fold is alsoexploited by the fatty acid-binding proteins, which function similarly bybinding small hydrophobic molecules. Similarity at the sequence level,however, is less obvious, being confined to a single short N-terminal motif.This entry represents the Lipocalin conserved site. The sequences of most members of the family, the core or kernal lipocalins, are characterised by three short conserved stretches of residues []. Others, the outlier lipocalin group, share only one or two of these. This signature pattern was built around the first, common to all outlier and kernal lipocalins, which occurs near the start of the first beta-strand.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

14 Found In

Id Name Short Name Type
IPR011038 Calycin-like Calycin-like Domain
IPR012674 Calycin Calycin Domain
IPR002345 Lipocalin Lipocalin Family
IPR002447 Beta-lactoglobulin Blactoglobulin Family
IPR002971 Major urinary protein Maj_urinary Family
IPR002972 Prostaglandin D synthase PstgldnD_synth Family
IPR002968 Alpha-1-microglobulin A1-microglobln Family
IPR003087 Neutrophil gelatinase-associated lipocalin N_gelatinase Family
IPR002969 Apolipoprotein D ApolipopD Family
IPR002446 Lipocalin, bacterial Lipocalin_bac Family
IPR022271 Lipocalin, ApoD type Lipocalin_ApoD Family
IPR002448 Odour-binding protein Odour-bd Family
IPR002449 Retinol binding protein/Purpurin Retinol-bd/Purpurin Family
IPR003057 Invertebrate colouration protein Invtbrt_color Family

0 Parent Features

4 Publications

First Author Title Year Journal Volume Pages
Flower DR Mouse oncogene protein 24p3 is a member of the lipocalin protein family. 1991 Biochem Biophys Res Commun 180 69-74
Flower DR Structure and sequence relationships in the lipocalins and related proteins. 1993 Protein Sci 2 753-61
Flower DR Multiple molecular recognition properties of the lipocalin protein family. 1995 J Mol Recognit 8 185-95
Pervaiz S Homology of beta-lactoglobulin, serum retinol-binding protein, and protein HC. 1985 Science 228 335-7

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)