InterPro : IPR000524

Name  Transcription regulator HTH, GntR Short Name  Tscrpt_reg_HTH_GntR
Type  Domain Description  Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilisrepressor of the gluconate operon []. Family members include GntR, HutC, KorA, NtaR, FadR, ExuR, FarR, DgoR and PhnF. The crystal structure of the FadR protein has been determined []. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector-binding or oligomerisation domain at the C terminus (). The DNA-binding domain is well conserved in structure for the whole of the GntR family, consisting of a 3-helical bundle core with a small beta-sheet (wing); the GntR winged helix structure is similar to that found in several other transcriptional regulator families. The regions outside the DNA-binding domain are more variable and are consequently used to define GntR subfamilies []. This entry represents the N-terminal DNA-binding domain of the GntR family.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

6 Found In

Id Name Short Name Type
IPR014178 Fatty acid response transcription factor FadR FA-response_TF_FadR Family
IPR010248 Histidine utilization repressor His_ut_repres Family
IPR012702 Phosphonate C-P lyase system, transcriptional regulator PhnF CP_lyase_PhnF Family
IPR012770 Trehalose operon transcriptional repressor TreR Family
IPR017722 Transcription regulator PhnR Tscrpt_reg_PhnR Family
IPR017723 Transcription regulator, 2-aminoethylphosphonate utilisation-associated Tscrpt_reg_AEP_util-assoc Family

1 Parent Features

Id Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain

3 Publications

First Author Title Year Journal Volume Pages
Haydon DJ A new family of bacterial regulatory proteins. 1991 FEMS Microbiol Lett 63 291-5
van Aalten DM Crystal structure of FadR, a fatty acid-responsive transcription factor with a novel acyl coenzyme A-binding fold. 2000 EMBO J 19 5167-77
Rigali S Subdivision of the helix-turn-helix GntR family of bacterial regulators in the FadR, HutC, MocR, and YtrA subfamilies. 2002 J Biol Chem 277 12507-15

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)