InterPro : IPR028412

Name  Ras-related protein Ral Short Name  Ral
Type  Family Description  Ral protein family, including RALA and RALB, belongs to the RAS family of small GTPases. Like other RAS GTPases, Ral proteins function as molecular switches alternating between inactive GDP-bound and active GT-bound states [].In humans, RALA and RALB are activated in tumour-derived cell lines. RALA severely impairs the anchorage-independent proliferation of cancer cell lines [], while RALB is required to suppress apoptotic checkpoint activation and is essential for the survival of a variety of tumour-derived cell lines []. RALA and RALB share the same effector molecules, such as SEC5 and EXO84. However, they seem to function in distinct but inter-related biological processes. RALA regulates the assembly interface of a full octameric exocyst complex through interaction with Sec5 and Exo84 []. The RALB/Sec5 effector complex is involved in the TBK1-dependent innate immune signaling [], while the interaction between PALB and EXO84 promotes the assembly of catalytically active ULK1 and the beclin-1-VPS34 autophagy initiation complex []. This entry also includes Xenopus RalA and RalB. RalB regulates the actin cytoskeleton during the early development and affects gastrulation [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

0 Found In

1 Parent Features

Id Name Short Name Type
IPR020849 Small GTPase superfamily, Ras type Small_GTPase_Ras Family

6 Publications

First Author Title Year Journal Volume Pages
Colicelli J Human RAS superfamily proteins and related GTPases. 2004 Sci STKE 2004 RE13
Lim KH Activation of RalA is critical for Ras-induced tumorigenesis of human cells. 2005 Cancer Cell 7 533-45
Chien Y RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival. 2006 Cell 127 157-70
Moskalenko S Ral GTPases regulate exocyst assembly through dual subunit interactions. 2003 J Biol Chem 278 51743-8
Simicek M The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response. 2013 Nat Cell Biol 15 1220-30
Lebreton S RLIP mediates downstream signalling from RalB to the actin cytoskeleton during Xenopus early development. 2004 Mech Dev 121 1481-94

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)