InterPro : IPR015643

Name  Peptidase C1A, cathepsin B Short Name  Peptidase_C1A_cathepsin-B
Type  Family Description  Cysteine peptidases have characteristic molecular topologies, which can be seen not only in their three-dimensional structures, but commonly also in the two-dimensional structures. These are peptidases in which the nucleophile is the sulphydryl group of a cysteine residue. Cysteine proteases are divided into clans (proteins which are evolutionary related), and further sub-divided into families, on the basis of the architecture of their catalytic dyad or triad []. This group of cysteine peptidases belong to MEROPS peptidase family C1, sub-family C1A (papain family, clan CA). It includes proteins classed as non-peptidase homologues. These are have either been shown experimentally to lack peptidase activity or lack one or more of the active site residues. This entry icludes cathepsin B and the CPC peptidases (cathepsin B-like) from Leishmania major, Leishmania mexicanaand Trypanosoma cruzi. Cathepsin B cysteine protease enzymes have been shown to be involved in a variety of different biological processes in eukaryotes. The isolation and characterisation of four distinct cathepsin B-like genes from Caenorhabditis eleganshas been reported [].
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

3 Contains

Id Name Short Name Type
IPR000668 Peptidase C1A, papain C-terminal Peptidase_C1A_C Domain
IPR012599 Peptidase C1A, propeptide Propeptide_C1A Domain
IPR000169 Cysteine peptidase, cysteine active site Pept_cys_AS Active_site

0 Found In

1 Parent Features

Id Name Short Name Type
IPR013128 Peptidase C1A Peptidase_C1A Family

2 Publications

First Author Title Year Journal Volume Pages
Barrett AJ Evolutionary lines of cysteine peptidases. 2001 Biol Chem 382 727-33
Larminie CG Isolation and characterization of four developmentally regulated cathepsin B-like cysteine protease genes from the nematode Caenorhabditis elegans. 1996 DNA Cell Biol 15 75-82



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)