InterPro : IPR023941

Name  Glutathione-regulated potassium-efflux system protein KefC Short Name  K_H_efflux_KefC
Type  Family Description  The kefC gene encodes a potassium-efflux system that is regulated by glutathione metabolites [, , ]. Full activation of KefC also requires a soluble regulatory protein, KefF [, ]. KefC belongs to the monovalent cation:proton antiporter 2(CPA2) transporter family TC 2.A.37 (

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

0 Found In

1 Parent Features

Id Name Short Name Type
IPR006036 Potassium uptake protein TrkA K_uptake_TrkA Family

5 Publications

First Author Title Year Journal Volume Pages
Munro AW The cloning and DNA sequence of the gene for the glutathione-regulated potassium-efflux system KefC of Escherichia coli. 1991 Mol Microbiol 5 607-16
Miller S Identification of an ancillary protein, YabF, required for activity of the KefC glutathione-gated potassium efflux system in Escherichia coli. 2000 J Bacteriol 182 6536-40
Ferguson GP Potassium channel activation by glutathione-S-conjugates in Escherichia coli: protection against methylglyoxal is mediated by cytoplasmic acidification. 1995 Mol Microbiol 17 1025-33
Miller S Mutations in the glutathione-gated KefC K+ efflux system of Escherichia coli that cause constitutive activation. 1997 J Biol Chem 272 24942-7
Lyngberg L KefF, the regulatory subunit of the potassium efflux system KefC, shows quinone oxidoreductase activity. 2011 J Bacteriol 193 4925-32

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)