InterPro : IPR029839

Name  Signal transducer and activator of transcription 4 Short Name  STAT4
Type  Family Description  STAT proteins have a dual function: signal transduction and activation of transcription. STAT proteins contain a DNA-binding domain, a transactivation domain, and an Src homology 2 (SH2) domain, which is required for dimerisation. When cytokines are bound to cell surface receptors, the associated Janus kinases (JAKs) are activated, leading to tyrosine phosphorylation of the given STAT proteins []. Phosphorylated STATs form dimers, translocate to the nucleus, and bind specific response elements to activate transcription of target genes [].Signal transducer and activator of transcription 4 (STAT4) transduces interleukin-12, interleukin-23, and type I interferon cytokine signals in T cells and monocytes [, ]. It plays an important role in CD4+ Th1 lineage differentiation and IFN-gamma protein expression by CD4+ T cells []. It is crucial for both innate and adaptive immune responses to viral infection [].Variations of the STAT4 gene affect the susceptibility to autoimmune diseases [], such as systemic lupus erythematosus 11 (SLEB11) []and rheumatoid arthritis (RA) [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

0 Found In

1 Parent Features

Id Name Short Name Type
IPR001217 Transcription factor STAT STAT Family

8 Publications

First Author Title Year Journal Volume Pages
Dulek DE STAT4 deficiency fails to induce lung Th2 or Th17 immunity following primary or secondary respiratory syncytial virus (RSV) challenge but enhances the lung RSV-specific CD8+ T cell immune response to secondary challenge. 2014 J Virol 88 9655-72
Kariuki SN Cutting edge: autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-alpha in lupus patients in vivo. 2009 J Immunol 182 34-8
Remmers EF STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. 2007 N Engl J Med 357 977-86
Watford WT Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4. 2004 Immunol Rev 202 139-56
Levy DE Stats: transcriptional control and biological impact. 2002 Nat Rev Mol Cell Biol 3 651-62
Shuai K Regulation of JAK-STAT signalling in the immune system. 2003 Nat Rev Immunol 3 900-11
Korman BD STAT4: genetics, mechanisms, and implications for autoimmunity. 2008 Curr Allergy Asthma Rep 8 398-403
Morinobu A STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation. 2002 Proc Natl Acad Sci U S A 99 12281-6

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)