InterPro : IPR029538

Name  Serine/arginine-rich splicing factor 1 Short Name  SRSF1
Type  Family Description  Serine/arginine-rich (SR) proteins constitute a conserved family of RNA-bindingproteins with roles in both constitutive and alternative splicing []. Typically, SR proteins contain an N-terminal RNA-binding domain and a C-terminal RS domain that acts to promote protein-protein interactions [].This entry represents the prototype member of the SR family, serine/arginine-rich splicing factor 1 (SRSF1 or SF2/ASF). SF2/ASF regulates constitutive and alternative splicing []. It has also been shown to regulate diverse aspects of gene regulation, including mRNA stability [], translation [], and transcription []. SF2/ASF is upregulated in several human tumours, including lung, colon, kidney, liver, pancreas and breast tumours [].
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7 Publications

First Author Title Year Journal Volume Pages
Long JC The SR protein family of splicing factors: master regulators of gene expression. 2009 Biochem J 417 15-27
Black DL Mechanisms of alternative pre-messenger RNA splicing. 2003 Annu Rev Biochem 72 291-336
Michlewski G The splicing factor SF2/ASF regulates translation initiation by enhancing phosphorylation of 4E-BP1. 2008 Mol Cell 30 179-89
Lemaire R Stability of a PKCI-1-related mRNA is controlled by the splicing factor ASF/SF2: a novel function for SR proteins. 2002 Genes Dev 16 594-607
Lin S The splicing factor SC35 has an active role in transcriptional elongation. 2008 Nat Struct Mol Biol 15 819-26
Kohtz JD Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors. 1994 Nature 368 119-24
Karni R The gene encoding the splicing factor SF2/ASF is a proto-oncogene. 2007 Nat Struct Mol Biol 14 185-93



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)