InterPro : IPR017068

Name  Protein disulphide-isomerase A4 Short Name  Protein_diS-isomerase_A4
Type  Family Description  This entry represents protein disulphide-isomerase A4 (also known as endoplasmic reticulum protein 72 kDa or ERp-72) (), which acts as a molecular ER chaperone. ER chaperones are critical not only for quality control of proteins processed in the ER, but also for regulation of ER signalling in response to ER stress []. ERp-72 catalyses the rearrangement of -S-S- bonds in proteins. It is part a large chaperone multiprotein complex comprising CABP1, DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. ERp-72 may functionally associate with NADPH oxidase 1 (NOX1) [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

3 Contains

Id Name Short Name Type
IPR013766 Thioredoxin domain Thioredoxin_domain Domain
IPR017937 Thioredoxin, conserved site Thioredoxin_CS Conserved_site
IPR005788 Disulphide isomerase Disulphide_isomerase Domain

0 Found In

1 Parent Features

Id Name Short Name Type
IPR005792 Protein disulphide isomerase Prot_disulphide_isomerase Family

2 Publications

First Author Title Year Journal Volume Pages
Ni M ER chaperones in mammalian development and human diseases. 2007 FEBS Lett 581 3641-51
Chen W A possible biochemical link between NADPH oxidase (Nox) 1 redox-signalling and ERp72. 2008 Biochem J 416 55-63

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)