InterPro : IPR005251

Name  Methylthioribose-1-phosphate isomerase Short Name  IF-M1Pi
Type  Family Description  This family contains proteins designated as 5-methylthioribose-1-phosphate isomerase (MTNA, , []). It also contains putative translation initiation factor 2B subunit proteins.5-methylthioribose-1-phosphate isomerase (MTNA) participates in the methionine salvage pathway catalysing the isomerisation of 5-methylthioribose-1-phosphate to 5-methylthio ribulose-1-phosphate []. The methionine salvage pathway leads to the synthesis of methionine from methylthioadenosine, the end product of the spermidine and spermine anabolism in many species.The delineation of this family is based in part on a discussion and neighbour-joining phylogenetic study [, ], of archaeal and other proteins homologous to the alpha, beta, and delta subunits of eukaryotic initiation factor 2B (eIF-2B), a five-subunit molecule that catalyzes GTP recycling for eIF-2. The archaeal proteins are related to the common ancestor of eIF-2B alpha, beta, and delta rather then specifically to any one of them, and that designation of particular archaeal members as corresponding to eIF-2B alpha or eIF-2B delta is imprecise. It has been suggested that designating the archaeal proteins as translation initiation factors remains unproven.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

0 Found In

1 Parent Features

Id Name Short Name Type
IPR011559 Initiation factor 2B alpha/beta/delta Initiation_fac_2B_a/b/d Family

4 Publications

First Author Title Year Journal Volume Pages
Bumann M Crystal structure of yeast Ypr118w, a methylthioribose-1-phosphate isomerase related to regulatory eIF2B subunits. 2004 J Biol Chem 279 37087-94
Ashida H A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO. 2003 Science 302 286-90
Kyrpides NC Archaeal translation initiation revisited: the initiation factor 2 and eukaryotic initiation factor 2B alpha-beta-delta subunit families. 1998 Proc Natl Acad Sci U S A 95 3726-30
Kyrpides NC Universally conserved translation initiation factors. 1998 Proc Natl Acad Sci U S A 95 224-8

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)