InterPro : IPR017202

Name  Sensor histidine kinase LiaS/VraS Short Name  LiaS/VraS
Type  Family Description  This entry represents signal transduction histidine kinases such as LiaS from Bacillus subtilis and VraS from Staphylococcus aureus. LiaS is a member of the two-component regulatory system LiaS (HK)/LiaR(RR), which is probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin) []. LiaS may also be involved in response to cationic antimicrobial peptides and secretion stress. VraS is a member of the two-component regulatory system VraS/VraR involved in the control of the cell wall peptidoglycan biosynthesis. It probably activates VraR by phosphorylation [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

2 Contains

Id Name Short Name Type
IPR003594 Histidine kinase-like ATPase, C-terminal domain HATPase_C Domain
IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain Sig_transdc_His_kin_sub3_dim/P Domain

0 Found In

0 Parent Features

2 Publications

First Author Title Year Journal Volume Pages
Kuroda M Identification of the up- and down-regulated genes in vancomycin-resistant Staphylococcus aureus strains Mu3 and Mu50 by cDNA differential hybridization method. 2000 Biochem Biophys Res Commun 269 485-90
Mascher T Intramembrane-sensing histidine kinases: a new family of cell envelope stress sensors in Firmicutes bacteria. 2006 FEMS Microbiol Lett 264 133-44

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)