InterPro : IPR020886

Name  Transcription regulator HTH, Cro/C1-type DNA-binding Short Name  Tscrpt_reg_HTH_Cro/C1
Type  Family Description  This is a family of archaeal proteins that contain a cro/C1-type HTH domain. The cro/C1-type HTH domain is a DNA-binding, helix-turn-helix (HTH) domain of about 50-60 residues present in transcriptional regulators. The domain is named after the transcriptional repressors Cro and C1 of temperate bacteriophages 434 and lambda, respectively. Besides in being the bacteriophages, cro/C1-type regulators are present in prokaryotes and in eukaryotes. The helix-turn-helix DNA-binding motif is generally located in the N-terminal part of these transcriptional regulators. The C-terminal part may contain an oligomerisation domain, e.g. C1 repressors and CopR act as dimers, while SinR is a tetramer. The cro/C1-type HTH domain also occurs in combination with the TPR repeat and the C-terminal part of C-5 cytosine-specific DNA methylases contains regions related to the enzymatic function (see ).

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

2 Contains

Id Name Short Name Type
IPR010982 Lambda repressor-like, DNA-binding domain Lambda_DNA-bd_dom Domain
IPR001387 Cro/C1-type helix-turn-helix domain Cro/C1-type_HTH Domain

0 Found In

0 Parent Features

0 Publications

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)