InterPro : IPR029539

Name  Calpain-2 Short Name  CAPN2
Type  Family Description  Calpain-2 (CAPN2, also known as m-calpain) belongs to the calpain family, which consists of a group of Ca2+ dependent cysteine proteases that regulate functions of substrates by proteolysis [, ]. The most abundant members of the calpain familiy are CAPN1 and CAPN2. They form heterodimers, which are regulated by a small regulatory subunit (28 kDa) encoded by the gene Capn4 []. CAPN2 is required for proteolysis of cytoskeletal and focal adhesion proteins, such as FAK, paxillin, spectrin, and talin []. The cleavage of the cytoskeletal protein talin-1 (TLN1) by CAPN2 is critical for the disassembly of focal adhesions [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

0 Found In

1 Parent Features

Id Name Short Name Type
IPR022684 Peptidase C2, calpain family Calpain_cysteine_protease Family

4 Publications

First Author Title Year Journal Volume Pages
Goll DE The calpain system. 2003 Physiol Rev 83 731-801
Jeong SY Calpain-dependent cytoskeletal rearrangement exploited for anthrax toxin endocytosis. 2013 Proc Natl Acad Sci U S A 110 E4007-15
Franco S Isoform specific function of calpain 2 in regulating membrane protrusion. 2004 Exp Cell Res 299 179-87
Shimada M In vivo targeted deletion of calpain small subunit, Capn4, in cells of the osteoblast lineage impairs cell proliferation, differentiation, and bone formation. 2008 J Biol Chem 283 21002-10

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)