InterPro : IPR029643

Name  Calpain-1 Short Name  CAPN1
Type  Family Description  Calpain-1 catalytic subunit (CAPN1, also known as mu-calpain) belongs to the calpain family, which consists of a group of Ca2+ dependent cysteine proteases that regulate functions of substrates by proteolysis [, ]. The most abundant members of the calpain familiy are CAPN1 and CAPN2. They form heterodimers, which are regulated by a small regulatory subunit (28 kDa) encoded by the gene Capn4 []. Calpain-1 plays a role in regulating IgE-mediated mast cell activation []. Calpain-1 is also involved in mammary gland remodelling [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

0 Found In

1 Parent Features

Id Name Short Name Type
IPR022684 Peptidase C2, calpain family Calpain_cysteine_protease Family

5 Publications

First Author Title Year Journal Volume Pages
Goll DE The calpain system. 2003 Physiol Rev 83 731-801
Jeong SY Calpain-dependent cytoskeletal rearrangement exploited for anthrax toxin endocytosis. 2013 Proc Natl Acad Sci U S A 110 E4007-15
Shimada M In vivo targeted deletion of calpain small subunit, Capn4, in cells of the osteoblast lineage impairs cell proliferation, differentiation, and bone formation. 2008 J Biol Chem 283 21002-10
Wu Z Calpain-1 contributes to IgE-mediated mast cell activation. 2014 J Immunol 192 5130-9
Arnandis T Differential functions of calpain 1 during epithelial cell death and adipocyte differentiation in mammary gland involution. 2014 Biochem J 459 355-68

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)