InterPro : IPR003801

Name  GTP cyclohydrolase FolE2/MptA Short Name  GTP_cyclohydrolase_FolE2/MptA
Type  Family Description  This is a family of prokaryotic/archaeal proteins with type I GTP cyclohydrolase activity. GTP cyclohydrolase I is the first enzyme of the de novo tetrahydrofolate biosynthetic pathway present in bacteria, fungi, and plants, and encoded in Escherichia coli by the folE gene []. FolE is Zinc 2+ dependent [].In bacteria GTP cyclohydrolase FolE2 converts GTP to 7,8-dihydroneopterin triphosphate []; while in the archaea GTP cyclohydrolase MptA converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



2 Child Features

Id Name Short Name Type
IPR022838 GTP cyclohydrolase FolE2 GTP_cyclohydrolase_FolE2 Family
IPR022840 GTP cyclohydrolase MptA GTP_cyclohydrolase_MptA Family

0 Contains

0 Found In

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
El Yacoubi B Discovery of a new prokaryotic type I GTP cyclohydrolase family. 2006 J Biol Chem 281 37586-93
Grochowski LL Characterization of an Fe(2+)-dependent archaeal-specific GTP cyclohydrolase, MptA, from Methanocaldococcus jannaschii. 2007 Biochemistry 46 6658-67
Sankaran B Zinc-independent folate biosynthesis: genetic, biochemical, and structural investigations reveal new metal dependence for GTP cyclohydrolase IB. 2009 J Bacteriol 191 6936-49

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)