InterPro : IPR010466

Name  Protein of unknown function DUF1058 Short Name  DUF1058
Type  Family Description  SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues [, ]. They are found in a great variety of intracellular or membrane-associated proteins [, , ]for example, in a variety of proteins with enzymatic activity, in adaptor proteins, such as fodrin and yeast actin binding protein ABP-1.The SH3 domain has a characteristic fold which consists of five or six beta-strands arranged as two tightly packed anti-parallel beta sheets. The linker regions may contain short helices. The surface of the SH3-domain bears a flat, hydrophobic ligand-binding pocket which consists of three shallow grooves defined by conservative aromatic residues in which the ligand adopts an extended left-handed helical arrangement. The ligand binds with low affinity but this may be enhanced by multiple interactions. The region bound by the SH3 domain is in all cases proline-rich and contains PXXP as a core-conserved binding motif. The function of the SH3 domain is not well understood but they may mediate many diverse processes such as increasing local concentration of proteins, altering their subcellular location and mediating the assembly of large multiprotein complexes [].This family consists of several hypothetical bacterial proteins of unknown function, but that contain an SH-3 region.
 Feedback

Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

1 Contains

Id Name Short Name Type
IPR003646 SH3-like domain, bacterial-type SH3-like_bac-type Domain

0 Found In

0 Parent Features

6 Publications

First Author Title Year Journal Volume Pages
Pawson T SH2 and SH3 domains. 1993 Curr Biol 3 434-42
Pawson T Protein modules and signalling networks. 1995 Nature 373 573-80
Mayer BJ Signalling through SH2 and SH3 domains. 1993 Trends Cell Biol 3 8-13
Morton CJ SH3 domains. Molecular 'Velcro'. 1994 Curr Biol 4 615-7
Musacchio A SH3--an abundant protein domain in search of a function. 1992 FEBS Lett 307 55-61
Mayer BJ SH3 domains: complexity in moderation. 2001 J Cell Sci 114 1253-63



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)