InterPro : IPR022308

Name  Synaptic vesicle protein SV2 Short Name  SV2
Type  Family Description  SV2 proteins are abundant synaptic vesicle proteins expressed in two major (SV2A and SV2B) and one minor isoform (SV2C) that resemble transporter proteins. SV2B knockout mice are phenotypically normal while SV2A- and SV2A/SV2Bdouble knockout mice exhibit severe seizures and die postnatally. Without SV2 proteins, presynaptic Ca2+accumulation during consecutive action potentials causes abnormal increases in neurotransmitter release that destabilise synaptic circuits and induce epilepsy [].
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

2 Contains

Id Name Short Name Type
IPR020846 Major facilitator superfamily domain MFS_dom Domain
IPR005829 Sugar transporter, conserved site Sugar_transporter_CS Conserved_site

0 Found In

1 Parent Features

Id Name Short Name Type
IPR011701 Major facilitator superfamily MFS Family

1 Publications

First Author Title Year Journal Volume Pages
Janz R SV2A and SV2B function as redundant Ca2+ regulators in neurotransmitter release. 1999 Neuron 24 1003-16



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)