InterPro : IPR003314

Name  Transposase MuA/Repressor CI, DNA-binding Short Name  MuA/CI_DNA-bd
Type  Domain Description  This family consists of MuA-transposase and repressor protein CI. The Bacteriophage Mutransposase is essential for integration, replication-transposition, and excision of Mu DNA. The N terminus of the Mu transposase has considerable sequence homology with the Mu repressor and with the NH2 terminus of the transposase of the Mu-like Bacteriophage D108. These three proteins are known to share binding sites on DNA. An internal sequence in the Mu A protein also shares these features [].The repressor protein of Bacteriophage Muestablishes and maintains lysogeny by shutting down transposition functions needed for phage DNA replication. It interacts with several repeated DNA sequences within the early operator, preventing transcription from two divergent promoters. It also directly represses transposition by competing with the MuA transposase for an internal activation sequence (IAS) that is coincident with the operator and required for efficient transposition. The transposase and repressor proteins compete for the operator/IAS region using homologous DNA-binding domains located at their amino termini [].
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

1 Contains

Id Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain

0 Found In

1 Parent Features

Id Name Short Name Type
IPR009061 DNA binding domain, putative DNA-bd_dom_put Domain

2 Publications

First Author Title Year Journal Volume Pages
Harshey RM Primary structure of phage mu transposase: homology to mu repressor. 1985 Proc Natl Acad Sci U S A 82 7676-80
Ilangovan U NMR structure and functional studies of the Mu repressor DNA-binding domain. 1999 Biochemistry 38 8367-76



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)