InterPro : IPR011559

Name  Initiation factor 2B alpha/beta/delta Short Name  Initiation_fac_2B_a/b/d
Type  Family Description  This family describes part of the eukaryotic translation initiation factor 2B superfamily. It includes eukaryotic translation initiation factor 2B (eIF-2B) subunits 1 and 2 (alpha and beta) and related proteins. Members of this branch of the family are predominantly uncharacterised with respect to function and are found in the archaea, bacteria, and eukarya.Recently, one of these proteins from Bacillus subtilishas been functionally characterised as a 5-methylthioribose-1-phosphate isomerase (MTNA, , []). This enzyme participates in the methionine salvage pathway catalysing the isomerisation of 5-methylthioribose-1-phosphate to 5-methylthio ribulose-1-phosphate []. The methionine salvage pathway leads to the synthesis of methionine from methylthioadenosine, the end product of the spermidine and spermine anabolism in many species.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



2 Child Features

Id Name Short Name Type
IPR005251 Methylthioribose-1-phosphate isomerase IF-M1Pi Family
IPR005250 Ribose-1,5-bisphosphate isomerase, e2b2 family Ribulose_e2b2 Family

0 Contains

0 Found In

1 Parent Features

Id Name Short Name Type
IPR000649 Initiation factor 2B-related IF-2B-related Family

2 Publications

First Author Title Year Journal Volume Pages
Bumann M Crystal structure of yeast Ypr118w, a methylthioribose-1-phosphate isomerase related to regulatory eIF2B subunits. 2004 J Biol Chem 279 37087-94
Ashida H A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO. 2003 Science 302 286-90

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)