InterPro : IPR013139

Name  Omega-atracotoxin, conserved site-2 Short Name  Omega_atracotoxin_CS2
Type  Conserved_site Description  Omega-atracotoxins (ACTX) form a family of neurotoxins that block insect but not vertebrate voltage-gated calcium channels. Omega-ACTXs are environmentally benign, insect-specific toxins that represent excellent leads for the development of new pesticides. Omega-ACTXs comprise a disulphide-rich region that has a [C-C-CC-C-C]arrangement and possess a Knottin scaffold [, , ]. The omega-ACTX type 2 family contains 43 to 45-residue toxins with a disordered C-terminal lipophilic extension []. This family includes omega-ACTX Hv2a from Hadronyche versuta(Blue mountains funnel-web spider) (Atrax versutus), omega ACTX As2a, As2b from Atrax sp. Illawarra(Funnel-web spider), and omega ACTX Hi2a, Hi2b from Hadronyche infensa(Fraser island funnel-web spider).

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

1 Found In

Id Name Short Name Type
IPR012628 Magi 5 toxic peptide Toxin_23 Family

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Fletcher JI The structure of a novel insecticidal neurotoxin, omega-atracotoxin-HV1, from the venom of an Australian funnel web spider. 1997 Nat Struct Biol 4 559-66
Wang X Structure-function studies of omega-atracotoxin, a potent antagonist of insect voltage-gated calcium channels. 1999 Eur J Biochem 264 488-94
Corzo G Pharmacologically active spider peptide toxins. 2003 Cell Mol Life Sci 60 2409-26

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)