InterPro : IPR011170

Name  Growth factor, vaccinia C11R type Short Name  GF_C11R
Type  Family Description  Virus-encoded growth factors (GF) are important for the virulence of poxviruses. They act to promote the growth of their host cell through their binding to host ErbB receptor tyrosine kinases, which in turn activate the MAPK pathway. These growth factors are related to mammalian epidermal growth factor (EGF), one of several host ErbB ligands. The viral GFs are potent mitogens, acting to prevent host receptor degradation and ubiquitination, which leads to sustained signal transduction. Growth factors from different poxviruses display unique patterns of specificity to host ErbB receptors: VGF (vaccinia virus GF) binds primarily to ErbB-1 homodimers, MGF (myxoma virus GF) binds to ErbB-2/ErbB-3 heterodimers, and SFGF (Shope fibroma virus GF) binds to different ErbB receptors [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

2 Contains

Id Name Short Name Type
IPR013032 EGF-like, conserved site EGF-like_CS Conserved_site
IPR000742 Epidermal growth factor-like domain EG-like_dom Domain

0 Found In

0 Parent Features

1 Publications

First Author Title Year Journal Volume Pages
Tzahar E Pathogenic poxviruses reveal viral strategies to exploit the ErbB signaling network. 1998 EMBO J 17 5948-63

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)