InterPro : IPR012707

Name  4-hydroxyphenylacetate permease Short Name  HPA_permease
Type  Family Description  Among the different families of transporter only two occur ubiquitously in all classifications of organisms. These are the ATP-Binding Cassette (ABC) superfamily and the Major Facilitator Superfamily (MFS). The MFS transporters are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients [, ].This entry represents a group of MFS proteins encoded in a number of proteobacterial genomes, but only in the context of having genes for 4-hydroxyphenylacetate (4-HPA) degradation. The protein is characterised as 4-HPA permease in Escherichia coli, where 3-HPA and 3,4-dihydroxyphenylacetate, but not other substrate analogues, were shown to competitively inhibit 4-HPA transport, indicating a narrow substrate specificity [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

0 Found In

1 Parent Features

Id Name Short Name Type
IPR011701 Major facilitator superfamily MFS Family

3 Publications

First Author Title Year Journal Volume Pages
Pao SS Major facilitator superfamily. 1998 Microbiol Mol Biol Rev 62 1-34
Walmsley AR Sugar transporters from bacteria, parasites and mammals: structure-activity relationships. 1998 Trends Biochem Sci 23 476-81
Prieto MA Identification of the 4-hydroxyphenylacetate transport gene of Escherichia coli W: construction of a highly sensitive cellular biosensor. 1997 FEBS Lett 414 293-7

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)