InterPro : IPR012499

Name  Janus-atracotoxin Short Name  Toxin_16
Type  Family Description  This family includes three peptides secreted by the spider Hadronyche versuta(Blue mountains funnel-web spider) (, , ). These are insect-selective, excitatory neurotoxins that may function by antagonising muscle acetylcholine receptors, or acetylcholine receptor subtypes present in other invertebrate neurons []. Janus atracotoxin-Hv1c (J-ACTX-Hv1c, ) is organised into a disulphide-rich globular core (residues 3-19) and a beta-hairpin (residues 20-34). There are 4 disulphide bridges, one of which is a vicinal disulphide bridge; this is known to be unimportant in the maintenance of structure but critical for insecticidal activity [].
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InterPro protein domain ID --> Contigs

 

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1 Publications

First Author Title Year Journal Volume Pages
Wang X Discovery and characterization of a family of insecticidal neurotoxins with a rare vicinal disulfide bridge. 2000 Nat Struct Biol 7 505-13



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)