InterPro : IPR019885

Name  Transcription regulator HTH, AsnC-type, conserved site Short Name  Tscrpt_reg_HTH_AsnC-type_CS
Type  Conserved_site Description  The many bacterial transcription regulation proteins which bind DNA through a'helix-turn-helix' motif can be classified into subfamilies on the basis ofsequence similarities. One such family is the AsnC/Lrp subfamily []. The Lrp family of transcriptional regulators appears to be widely distributed among bacteria andarchaea, as an important regulatory system of the amino acid metabolism and related processes []. Members of the Lrp family are small DNA-binding proteins with molecular masses of around15 kDa. Target promoters often contain anumber of binding sites that typically lack obvious inverted repeat elements, and to which binding isusually co-operative. LrpA from Pyrococcus furiosusis the first Lrp-like protein to date of which a three-dimensional structurehas been solved. In the crystal structure LrpA forms an octamer consistingof four dimers. The structure revealed that the N-terminal part of the protein consists of ahelix-turn-helix (HTH) domain, a fold generally involved in DNA binding.The C terminus of Lrp-like proteins has a beta-fold, where the two alpha-helices are located at one side of the four-stranded antiparallel beta-sheet.LrpA forms a homodimer mainly through interactions between the beta-strands of this C-terminaldomain, and an octamer through further interactions between the second alpha-helix and fourth beta-strandof the motif. Hence, the C-terminal domain of Lrp-like proteins appears tobe involved in ligand-response and activation [].This entry represents a conserved site that spans the complete helix-turn-helix motif and extends one residue downstream and one upstream of the HTH extremities.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

3 Found In

Id Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain
IPR000485 AsnC-type HTH domain AsnC-type_HTH_dom Domain
IPR019888 Transcription regulator AsnC-type Tscrpt_reg_AsnC-typ Family

0 Parent Features

2 Publications

First Author Title Year Journal Volume Pages
Kyrpides NC The eubacterial transcriptional activator Lrp is present in the archaeon Pyrococcus furiosus. 1995 Trends Biochem Sci 20 140-1
Brinkman AB The Lrp family of transcriptional regulators. 2003 Mol Microbiol 48 287-94

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)