InterPro : IPR011184

Name  DNA mismatch repair protein, MSH2 Short Name  DNA_mismatch_repair_MSH2
Type  Family Description  Mismatch repair is one of five major DNA repair pathways, the others being homologous recombination repair, non-homologous end joining, nucleotide excision repair, and base excision repair. The mismatch repair system recognises and repairs mispaired or unpaired nucleotides that result from errors in DNA replication. Many proteins involved in the different repair processes also play a role in apoptosis when DNA damage is excessive, thereby helping to prevent carcinogenesis []. The mismatch repair protein, Msh2 (MutS homologue 2), has a dual role in DNA repair and apoptosis. Msh2 acts as a heterodimer with Msh6, which together function to recruit the Mlh (MutL homologue) - Pms (post-meiotic segregation) heterodimer, and to replace the mispaired base [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

5 Contains

Id Name Short Name Type
IPR007696 DNA mismatch repair protein MutS, core DNA_mismatch_repair_MutS_core Domain
IPR000432 DNA mismatch repair protein MutS, C-terminal DNA_mismatch_repair_MutS_C Domain
IPR007861 DNA mismatch repair protein MutS, clamp DNA_mismatch_repair_MutS_clamp Domain
IPR007860 DNA mismatch repair protein MutS, connector domain DNA_mmatch_repair_MutS_con_dom Domain
IPR007695 DNA mismatch repair protein MutS-like, N-terminal DNA_mismatch_repair_MutS-lik_N Domain

0 Found In

0 Parent Features

2 Publications

First Author Title Year Journal Volume Pages
Bernstein C DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis. 2002 Mutat Res 511 145-78
Drotschmann K DNA binding properties of the yeast Msh2-Msh6 and Mlh1-Pms1 heterodimers. 2002 Biol Chem 383 969-75

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)