InterPro : IPR012224

Name  Peptidase S1A, coagulation factor VII/IX/X/C/Z Short Name  Pept_S1A_FX
Type  Family Description  This group of plasma glycoproteins includes coagulation factors VII, IX, and X, and proteins C and Z, which belong to MEROPS peptidase family S1, subfamily S1A (chymotrypsin, clan PA(S)). All but protein Z are peptidases and are involved in blood coagulation. The precursors contain a signal sequence, propeptide, Gla domain, two EGF domains (although sometimes only one is detected by Pfam), and a trypsin domain. Except for protein Z, they are further cleaved between the second EGF domain and the trypsin domain into light and heavy chains, which are connected by a disulphide bond. Glutamic acid residues in the Gla domain undergo vitamin K-dependent carboxylation, allowing this region to bind calcium and membrane phospholipid []. The propeptide region is important in providing a recognition site for the gamma-carboxylase []. Typically one aspartic acid residue in the light chain is post-translationally modified to erythro-beta-hydroxyaspartic acid [, ].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

5 Contains

Id Name Short Name Type
IPR013032 EGF-like, conserved site EGF-like_CS Conserved_site
IPR000742 Epidermal growth factor-like domain EG-like_dom Domain
IPR018097 EGF-like calcium-binding, conserved site EGF_Ca-bd_CS Conserved_site
IPR018114 Peptidase S1, trypsin family, active site Peptidase_S1_AS Active_site
IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain GLA_domain Domain

0 Found In

1 Parent Features

Id Name Short Name Type
IPR001314 Peptidase S1A, chymotrypsin-type Peptidase_S1A Family

4 Publications

First Author Title Year Journal Volume Pages
Freedman SJ Identification of the phospholipid binding site in the vitamin K-dependent blood coagulation protein factor IX. 1996 J Biol Chem 271 16227-36
Fernlund P Beta-hydroxyaspartic acid in vitamin K-dependent proteins. 1983 J Biol Chem 258 12509-12
McMullen BA The occurrence of beta-hydroxyaspartic acid in the vitamin K-dependent blood coagulation zymogens. 1983 Biochem Biophys Res Commun 115 8-14
Stanley TB The propeptides of the vitamin K-dependent proteins possess different affinities for the vitamin K-dependent carboxylase. 1999 J Biol Chem 274 16940-4

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)