InterPro : IPR017314

Name  Peptidase S8A, subtilisin-like peptidase 1, plasmodium Short Name  Pept_S8A_PfSUB_1
Type  Family Description  This entry contains serine peptidases belonging to MEROPS peptidase family S8A (subtilisin family, clan SB). All of the peptidases in this entry derive from Plasmodium spp. and are called 'subtilisin-like peptidase 1'.The peptidase in Plasmodium falciparum(isolate 3D7) termed pfSUB1 is a component of the exoneme []. PfSUB1 mediates the proteolytic maturation of at least two essential members of another enzyme family calledSERA. This proteolytic processing event is required for the releaseof viable parasites from the host erythrocyte [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

2 Contains

Id Name Short Name Type
IPR000209 Peptidase S8/S53 domain Peptidase_S8/S53_dom Domain
IPR022398 Peptidase S8, subtilisin, His-active site Peptidase_S8_His-AS Active_site

0 Found In

1 Parent Features

Id Name Short Name Type
IPR015500 Peptidase S8, subtilisin-related Peptidase_S8_subtilisin-rel Family

2 Publications

First Author Title Year Journal Volume Pages
Janse CJ The exoneme helps malaria parasites to break out of blood cells. 2007 Cell 131 1036-8
Yeoh S Subcellular discharge of a serine protease mediates release of invasive malaria parasites from host erythrocytes. 2007 Cell 131 1072-83

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)