InterPro : IPR017306

Name  Peptidase S8A, fervidolysin Short Name  Peptidase_S8A_fervidolysin
Type  Family Description  This entry contains serine peptidases belonging to MEROPS peptidase family S8A (subtilisin family, clan SB). Fervidolysin, from Fervidobacterium pennivoransis synthesized in an immature form with a propeptide (PD)-bound to the active site, once activated it is involved in the degradation of keratin. The crystal structure of fervidolysin has been resolved to 1.7A. It is composed of four domains: a catalytic domain (CD), two beta-sandwich domains (SDs), and the PD domain. Structural alignment shows a distant relationship between the PD-CD substructure of fervidolysin and pro-subtilisin E [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

3 Contains

Id Name Short Name Type
IPR000209 Peptidase S8/S53 domain Peptidase_S8/S53_dom Domain
IPR022398 Peptidase S8, subtilisin, His-active site Peptidase_S8_His-AS Active_site
IPR007280 Peptidase, C-terminal, archaeal/bacterial Peptidase_C_arc/bac Domain

0 Found In

1 Parent Features

Id Name Short Name Type
IPR015500 Peptidase S8, subtilisin-related Peptidase_S8_subtilisin-rel Family

1 Publications

First Author Title Year Journal Volume Pages
Kim JS Crystal structure of fervidolysin from Fervidobacterium pennivorans, a keratinolytic enzyme related to subtilisin. 2004 J Mol Biol 335 787-97

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)