InterPro : IPR008357

Name  Lantibiotic leader peptide-processing serine protease Short Name  Lanit_process
Type  Family Description  Lantibiotic genes reside on the bacterial chromosome, where they cluster with genes that adapt and secrete them to the extracellular space. Many of these so-called 'pathogenicity islands' have been characterised, including the epidermin (epi) cluster in Staphylococcus epidermis, and the nisin (nis) cluster in Lactococcus lactis[]. The gene encoding the lantibiotic is flanked by 3 regulatory genes: 2 that are usually involved ina 2-component regulatory system, and another that cleaves the signal peptide from the precursor to produce the mature lantibiotic.This protein (usually designated with a "P" suffix - nisP, mutP, etc.) is highly conserved amongst pathogenic species, and is essential for virulence and survival of the bacterium against competitors in the host []. Recently, a novel pathogenicity island in resistant Enterococcus faecaliswas sequenced. In addition to the lantibiotic Cyl gene cluster, this revealed a novel set of virulence factors involved in vancomycin resistance and pathogenicity [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

2 Contains

Id Name Short Name Type
IPR000209 Peptidase S8/S53 domain Peptidase_S8/S53_dom Domain
IPR022398 Peptidase S8, subtilisin, His-active site Peptidase_S8_His-AS Active_site

0 Found In

1 Parent Features

Id Name Short Name Type
IPR015500 Peptidase S8, subtilisin-related Peptidase_S8_subtilisin-rel Family

2 Publications

First Author Title Year Journal Volume Pages
Qi F The group I strain of Streptococcus mutans, UA140, produces both the lantibiotic mutacin I and a nonlantibiotic bacteriocin, mutacin IV. 2001 Appl Environ Microbiol 67 15-21
Shankar N Modulation of virulence within a pathogenicity island in vancomycin-resistant Enterococcus faecalis. 2002 Nature 417 746-50

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)