InterPro : IPR005736

Name  Reverse gyrase Short Name  Reverse_gyrase
Type  Family Description  This entry represents reverse gyrases found in both bacteria and archaea. Reverse gyrase, a fusion of a type I topoisomerase domain and a helicase domain, introduces positive supercoiling to increase the melting temperature of DNA double strands. Generally, these gyrases are encoded as a single polypeptide. An exception was found in Methanopyrus kandleri, where enzyme is split within the topoisomerase domain, yielding a heterodimer of gene products designated RgyB and RgyA. DNA topoisomerases are divided into two classes: type I enzymes (; topoisomerases I, III and V) break single-strand DNA, and type II enzymes (; topoisomerases II, IV and VI) break double-strand DNA []. Type I topoisomerases can be subdivided according to their structure and reaction mechanisms: type IA (bacterial and archaeal topoisomerase I, topoisomerase III and reverse gyrase) and type IB (eukaryotic topoisomerase I and topoisomerase V). Most of the Type I topoisomerases are ATP-independent and are responsible for relaxing positively and/or negatively supercoiled DNA. Reverse gyrase is a unique type IA topoisomerase in that it requires ATP and can introduce positive supercoils into DNA.
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Sequence Features

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Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

5 Contains

Id Name Short Name Type
IPR011545 DEAD/DEAH box helicase domain DEAD/DEAH_box_helicase_dom Domain
IPR013497 DNA topoisomerase, type IA, central Topo_IA_cen Domain
IPR003602 DNA topoisomerase, type IA, DNA-binding domain Topo_IA_DNA-bd_dom Domain
IPR003601 DNA topoisomerase, type IA, domain 2 Topo_IA_2 Domain
IPR013824 DNA topoisomerase, type IA, central region, subdomain 1 Topo_IA_cen_sub1 Domain

0 Found In

1 Parent Features

Id Name Short Name Type
IPR000380 DNA topoisomerase, type IA Topo_IA Family

1 Publications

First Author Title Year Journal Volume Pages
Gadelle D Phylogenomics of type II DNA topoisomerases. 2003 Bioessays 25 232-42



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)