InterPro : IPR001416

Name  CXC chemokine receptor 7 Short Name  Chemokine_CXCR7
Type  Family Description  Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).This entry represents CXC chemokine receptor 7 (CXCR7) it causes chemotaxis in T lymphocytes in response to CXCL12 (SDF1) []. CXCR7 can also bind CXCL11 [], which is an established ligand for CXCR3 []. CXCR7 has been given chemokine receptor status from the International Union of Basic and Clinical Pharmacology (IUPHAR) but it has been subsequently shown that unlike other CXC chemokine receptors, CXCR7 does not elicit classical chemokine receptor signalling via typical G protein-mediated pathways [], but instead induces beta-arrestin recruitment, leading to ligand internalisation and activation of MAPK signaling pathway [, ]. CXCR7 is therefore regarded as acting as a scavenger for CXCL12 and, to a lesser extent, for CXCL11 []. CXCR7 has been identified on memory B cells and in mammals is found in bone, brain, heart and kidney [, ]. It has been shown to act as a novel coreceptor for several immunodeficiency virus strains, which infect brain-derived cells []. Studies of reduced CXCR7 expression in zebrafish have also revealled a critical role in vascular formation and angiogenesis during development []. CXCR7 has also been shown to promote growth of tumors formed from breast and lung cancer cells [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

0 Found In

1 Parent Features

Id Name Short Name Type
IPR000355 Chemokine receptor family Chemokine_rcpt Family

16 Publications

First Author Title Year Journal Volume Pages
Horuk R Chemokine receptors. 2001 Cytokine Growth Factor Rev 12 313-35
Zlotnik A Chemokines: a new classification system and their role in immunity. 2000 Immunity 12 121-7
Charbonnier AS Macrophage inflammatory protein 3alpha is involved in the constitutive trafficking of epidermal langerhans cells. 1999 J Exp Med 190 1755-68
Sallusto F Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. 1998 J Exp Med 187 875-83
Ma Q Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. 1998 Proc Natl Acad Sci U S A 95 9448-53
Strieter RM The functional role of the ELR motif in CXC chemokine-mediated angiogenesis. 1995 J Biol Chem 270 27348-57
Naumann U CXCR7 functions as a scavenger for CXCL12 and CXCL11. 2010 PLoS One 5 e9175
Balabanian K The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes. 2005 J Biol Chem 280 35760-6
Singh AK Chemokine receptor trio: CXCR3, CXCR4 and CXCR7 crosstalk via CXCL11 and CXCL12. 2013 Cytokine Growth Factor Rev 24 41-9
Shimizu N A putative G protein-coupled receptor, RDC1, is a novel coreceptor for human and simian immunodeficiency viruses. 2000 J Virol 74 619-26
Gerrits H Early postnatal lethality and cardiovascular defects in CXCR7-deficient mice. 2008 Genesis 46 235-45
Sierro F Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7. 2007 Proc Natl Acad Sci U S A 104 14759-64
Rajagopal S Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7. 2010 Proc Natl Acad Sci U S A 107 628-32
Burns JM A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development. 2006 J Exp Med 203 2201-13
Miao Z CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature. 2007 Proc Natl Acad Sci U S A 104 15735-40
Zabel BA Elucidation of CXCR7-mediated signaling events and inhibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligands. 2009 J Immunol 183 3204-11

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)