InterPro : IPR008261

Name  Iodothyronine deiodinase, active site Short Name  Iodothyronine_deiodinase_AS
Type  Active_site Description  Iodothyronine deiodinase () (DI) []is the vertebrate enzyme responsible for the deiodination ofthe prohormone thyroxine (T4 or 3,5,3',5'-tetraiodothyronine) into the biologically active hormone T3(3,5,3'-triiodothyronine) and of T3 into the inactive metabolite T2 (3,3'-diiodothyronine). All known DI areproteins of about 250 residues that contain a selenocysteine at their active site. Three types of DI areknown, type II is essential for providing the brain with the appropriate levels of T3 during the criticalperiod of development, and type III is essential for the regulation of thyroid hormone inactivation duringembryological development. This signature found in the central part of the enzyme, which contains the active site selenocysteine.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

2 Found In

Id Name Short Name Type
IPR012336 Thioredoxin-like fold Thioredoxin-like_fold Domain
IPR000643 Iodothyronine deiodinase Iodothyronine_deiodinase Family

0 Parent Features

1 Publications

First Author Title Year Journal Volume Pages
Davey JC Cloning of a cDNA for the type II iodothyronine deiodinase. 1995 J Biol Chem 270 26786-9

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)