InterPro : IPR000317

Name  Peptidase C24, Calicivirus polyprotein Orf1 Short Name  Peptidase_C24
Type  Domain Description  Cysteine peptidases have characteristic molecular topologies, which can be seen not only in their three-dimensional structures, but commonly also in the two-dimensional structures. These are peptidases in which the nucleophile is the sulphydryl group of a cysteine residue. Cysteine proteases are divided into clans (proteins which are evolutionary related), and further sub-divided into families, on the basis of the architecture of their catalytic dyad or triad []. The two signatures that defines this group of calivirus polyproteins identify a cysteine peptidase signature that belongs to MEROPS peptidase family C24 (clan PA(C)). Caliciviruses are positive-stranded ssRNA viruses that cause gastroenteritis. The calicivirus genome contains two open reading frames, ORF1 and ORF2. ORF2 encodes a structural protein []; while ORF1 encodes a non-structural polypeptide, which has RNA helicase, cysteineprotease and RNA polymerase activity. The regions of the polyprotein inwhich these activities lie are similar to proteins produced by the picornaviruses. Two different families of caliciviruses can be distinguished on the basis of sequence similarity, namely those classified as small round structured viruses (SRSVs) and those classed as non-SRSVs.Calicivirus proteases from the non-SRSV group, which are members of the PAprotease clan, constitute family C24 of the cysteine proteases (proteasesfrom SRSVs belong to the C37 family). As mentioned above, the proteaseactivity resides within a polyprotein. The enzyme cleaves the polyproteinat sites N-terminal to itself, liberating the polyprotein helicase.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

0 Found In

1 Parent Features

Id Name Short Name Type
IPR009003 Trypsin-like cysteine/serine peptidase domain Trypsin-like_Pept_dom Domain

2 Publications

First Author Title Year Journal Volume Pages
Barrett AJ Evolutionary lines of cysteine peptidases. 2001 Biol Chem 382 727-33
Wirblich C Genetic map of the calicivirus rabbit hemorrhagic disease virus as deduced from in vitro translation studies. 1996 J Virol 70 7974-83

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)