InterPro : IPR012006

Name  tRNA nucleotidyltransferase, proteobacteria Short Name  CCA_bact
Type  Family Description  This family predominantly consists of bacterial versions of tRNA adenylyltransferases. tRNA nuceotidyltransferases are responsible for the synthesis or repair of the 3' terminal CCA sequence of tRNA molecules. They are encoded by essential genes in almost all organisms and add the three ribonucleotides C, C, and A to the 3' end of tRNAs in sequential order. Most members of this family contain an additional metal dependent phosphohydrolase domain (HD). Although the precise functional role of this domain is undetermined, the demonstration in Escherichia coliof 2',3'-cyclic phosphodiesterase, 2'-nucleotidase, and phosphatase activities has led to the suggestion that it is involved in the repair of the CCA terminus [].For additional information please see [, , , , ].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

2 Contains

Id Name Short Name Type
IPR002646 Poly A polymerase, head domain PolA_pol_head_dom Domain
IPR003607 HD/PDEase domain HD/PDEase_dom Domain

0 Found In

0 Parent Features

6 Publications

First Author Title Year Journal Volume Pages
Wolf YI Evolution of aminoacyl-tRNA synthetases--analysis of unique domain architectures and phylogenetic trees reveals a complex history of horizontal gene transfer events. 1999 Genome Res 9 689-710
Aravind L The HD domain defines a new superfamily of metal-dependent phosphohydrolases. 1998 Trends Biochem Sci 23 469-72
Aravind L DNA polymerase beta-like nucleotidyltransferase superfamily: identification of three new families, classification and evolutionary history. 1999 Nucleic Acids Res 27 1609-18
Galperin MY A specialized version of the HD hydrolase domain implicated in signal transduction. 1999 J Mol Microbiol Biotechnol 1 303-5
Li F Crystal structures of the Bacillus stearothermophilus CCA-adding enzyme and its complexes with ATP or CTP. 2002 Cell 111 815-24
Yakunin AF The HD domain of the Escherichia coli tRNA nucleotidyltransferase has 2',3'-cyclic phosphodiesterase, 2'-nucleotidase, and phosphatase activities. 2004 J Biol Chem 279 36819-27

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)