InterPro : IPR011244

Name  Bifunctional argininosuccinate lyase/acetyltransferase Short Name  ASAL_AGS_AcTrfase
Type  Family Description  This group represents a predicted bifunctional argininosuccinate lyase/acetyltransferase from Gammaproteobacteria. Bifunctional enzymes permit the direct channelling of intermediates between catalytic centres involved in consecutive reactions in a pathway, offering an efficient means of directing the flow of catalysis and protecting intermediates from degradation []. Both the argininosuccinate lyase () activity and the acetyltransferase () activity are involved in arginine biosynthesis in bacteria, where argininosuccinate lyase catalyses the conversion of N-(L-arginino)succinate to fumarate and L-arginine [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

3 Contains

Id Name Short Name Type
IPR000182 GNAT domain GNAT_dom Domain
IPR022761 Fumarate lyase, N-terminal Fumarate_lyase_N Domain
IPR020557 Fumarate lyase, conserved site Fumarate_lyase_CS Conserved_site

0 Found In

0 Parent Features

2 Publications

First Author Title Year Journal Volume Pages
Nagradova N Interdomain communications in bifunctional enzymes: how are different activities coordinated? 2003 IUBMB Life 55 459-66
Haas D The genetic organization of arginine biosynthesis in Pseudomonas aeruginosa. 1977 Mol Gen Genet 154 7-22

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)