InterPro : IPR010167

Name  Amino-acid N-acetyltransferase (ArgA) Short Name  NH2A_AcTrfase_ArgA
Type  Family Description  This entry represents amino-acid N-acetyltransferase or N-acetylglutamate synthase, which is the product of the argA gene and the first enzyme in arginine biosynthesis. This enzyme displays more diversity between bacteria, fungi and mammals than other enzymes in arginine metabolism, and N-acetylglutamate itself can have different roles in different taxonomic groups: in prokaryotes, lower eukaryotes and plants it is the first intermediate in arginine biosynthesis, while in vertebrates it is an allosteric cofactor for the first enzyme in the urea cycle []. In bacteria, arginine can regulate ornithine biosynthesis via a feedback inhibition mechanism []. This enzyme may also act on aspartate.
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

2 Contains

Id Name Short Name Type
IPR000182 GNAT domain GNAT_dom Domain
IPR001048 Aspartate/glutamate/uridylate kinase Asp/Glu/Uridylate_kinase Domain

0 Found In

0 Parent Features

2 Publications

First Author Title Year Journal Volume Pages
Caldovic L N-acetylglutamate and its changing role through evolution. 2003 Biochem J 372 279-90
Rajagopal BS Use of inducible feedback-resistant N-acetylglutamate synthetase (argA) genes for enhanced arginine biosynthesis by genetically engineered Escherichia coli K-12 strains. 1998 Appl Environ Microbiol 64 1805-11



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)