InterPro : IPR017813

Name  Mycothiol acetyltransferase Short Name  Mycothiol_AcTrfase
Type  Family Description  Low-molecular weight thiols play an essential role in the metabolism of organsism as coenzymes and cofactors that facilitate important biochemical processes in conjunction with proteins. The predominant low-molecular weight thiol in the actinomycetes is mycothiol, which is involved in the maintenance of cellualar redox state, detoxification of electrophiles and resistance to antimicrobials [, ]. The pathway of mycothiol biosynthesis is therefore a potential target for the development of new drugs to treat pathogenic actinomycetes such as Mycobacterium tuberculosis.This entry represents the MshD protein catalysing the final step of mycothiol biosynthesis, the acetylation of the cysteinyl amine in cysteine-glucosamine-inositol (Cys-GlcN-Ins) []. MshD is a monomeric enzyme consisting of two tandemly-repeated domains which each adopt the GCN5-related N-acetyltransferase (GNAT) fold [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

1 Contains

Id Name Short Name Type
IPR000182 GNAT domain GNAT_dom Domain

0 Found In

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Fahey RC Novel thiols of prokaryotes. 2001 Annu Rev Microbiol 55 333-56
Rawat M Mycothiol-deficient Mycobacterium smegmatis mutants are hypersensitive to alkylating agents, free radicals, and antibiotics. 2002 Antimicrob Agents Chemother 46 3348-55
Koledin T Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes. 2002 Arch Microbiol 178 331-7

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)