InterPro : IPR001491

Name  Thrombomodulin Short Name  Thrombomodulin
Type  Family Description  Thrombomodulin is an endothelial cell thrombin receptor that convertsthrombin from a procoagulant to an anticoagulant enzyme [, ]. Thrombomodulin forms a 1:1 stoichiometric complex with thrombin that is responsible for the conversion ofprotein C to the activated protein CA. Protein CA scissions the activated cofactors of the coagulation mechanism, factors VA and VIIIA, and thereby reduces the amount of thrombin generated.The thrombin-bound structures of peptide fragments from the fifth EGF-likedomain of thrombomodulin have been determined by NMR and transferred NOEspectroscopy []. The peptides assume an EGF-like structure, with an anti-parallel beta-sheet, which shows structural resilience in accommodating different numbers of residues within its disulphide loop. The keycontacts with thrombin are hydrophobic interactions between the side chainsof residues Ile 414 and Ile 424 of thrombomodulin and a hydrophobic pocketon the thrombin surface. The unique beta-sheet structures of the boundpeptides are specified by the presence of disulphide bridges; correspondinglinear thrombomodulin fragments fold into sheet structures with differentbackbone topologies.
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Sequence Features

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Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

6 Contains

Id Name Short Name Type
IPR013032 EGF-like, conserved site EGF-like_CS Conserved_site
IPR001881 EGF-like calcium-binding domain EGF-like_Ca-bd_dom Domain
IPR000742 Epidermal growth factor-like domain EG-like_dom Domain
IPR000152 EGF-type aspartate/asparagine hydroxylation site EGF-type_Asp/Asn_hydroxyl_site PTM
IPR018097 EGF-like calcium-binding, conserved site EGF_Ca-bd_CS Conserved_site
IPR015149 Thrombomodulin-like, EGF-like Tme5_EGF-like Domain

0 Found In

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Gerlitz B Identification of the predominant glycosaminoglycan-attachment site in soluble recombinant human thrombomodulin: potential regulation of functionality by glycosyltransferase competition for serine474. 1993 Biochem J 295 ( Pt 1) 131-40
Dittman WA The structure and function of mouse thrombomodulin. Phorbol myristate acetate stimulates degradation and synthesis of thrombomodulin without affecting mRNA levels in hemangioma cells. 1988 J Biol Chem 263 15815-22
Hrabal R Structural resiliency of an EGF-like subdomain bound to its target protein, thrombin. 1996 Protein Sci 5 195-203



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)