InterPro : IPR020539

Name  Ribonuclease P, conserved site Short Name  RNase_P_CS
Type  Conserved_site Description  Ribonuclease P () (RNase P) [, , ]is a site specific endonuclease that generates mature tRNAs by catalysing the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. In bacteria RNase P is known to be composed of two components: a large RNA (about 400 base pairs) encoded by rnpB, and a small protein (119 to 133 amino acids) encoded by rnpA. The RNA moiety of RNase P carries the catalytic activity; the protein component plays an auxiliary, but essential, role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.The sequence of rnpA is not highly conserved, however there is, in the centralpart of the protein, a conserved basic region.This entry represents a conserved basic region found towards the centre of ribonuclease P.
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

0 Contains

3 Found In

Id Name Short Name Type
IPR020568 Ribosomal protein S5 domain 2-type fold Ribosomal_S5_D2-typ_fold Domain
IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup Ribosomal_S5_D2-typ_fold_subgr Domain
IPR000100 Ribonuclease P RNase_P Family

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Altman S Ribonuclease P. Postscript. 1990 J Biol Chem 265 20053-6
Pace NR Ribonuclease P: function and variation. 1990 J Biol Chem 265 3587-90
Brown JW Ribonuclease P RNA and protein subunits from bacteria. 1992 Nucleic Acids Res 20 1451-6



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)