InterPro : IPR010189

Name  Shikimate kinase, archaea Short Name  SK_arc
Type  Family Description  Shikimate kinase () catalyses the fifth step in the shikimate pathway of aromatic amino acids biosynthesis. It converts shikimate to shikimate 3-phosphate (3-phosphoshikimate). This part of the pathway leads to the biosynthesis of chorismate, the precursor of aromatic amino acids, folates, ubiquinones, and other aromatic compounds. The shikimate pathway links metabolism of carbohydrates to biosynthesis of the aromatic amino acids phenylalanine, tyrosine, tryptophan and their derivatives in microorganisms and plants []. In a sequence of seven enzymatic reactions, D-erythrose 4-phosphate (E4P), an intermediate of the pentose phosphate pathway and phosphoenol pyruvate (PEP), a glycolytic intermediate, are converted to chorismate. The shikimate pathway is present in bacteria, archaea, fungi and plants. The absence of the shikimate pathway in animals makes it an attractive target for non-toxic herbicides, antimicrobial and antifungal agents.Shikimate kinase enzymes present an example of convergent evolution via enzyme recruitment from an unrelated group. This group represents shikimate kinases of the archaeal type. Members have no sequence similarity with the typical form of shikimate kinase (, ) found in bacteria and eukaryotes, but are instead distantly related to homoserine kinases, which belong to the GHMP kinase domain superfamily (GHMP = galactose, homoserine, mevalonate, and phosphomevalonate) []. All known non-archaeal shikimate kinases (the typical form) belong to the non-homologous, structurally unrelated nucleoside monophosphate (NMP) kinase domain superfamily [].Nomenclature note: the name AroK is used for non-homologous shikimate kinases of both the archaeal and bacterial types.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

4 Contains

Id Name Short Name Type
IPR020568 Ribosomal protein S5 domain 2-type fold Ribosomal_S5_D2-typ_fold Domain
IPR013750 GHMP kinase, C-terminal domain GHMP_kinase_C_dom Domain
IPR006204 GHMP kinase N-terminal domain GHMP_kinase_N_dom Domain
IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup Ribosomal_S5_D2-typ_fold_subgr Domain

0 Found In

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Krell T The three-dimensional structure of shikimate kinase. 1998 J Mol Biol 278 983-97
Herrmann KM THE SHIKIMATE PATHWAY. 1999 Annu Rev Plant Physiol Plant Mol Biol 50 473-503
Daugherty M Archaeal shikimate kinase, a new member of the GHMP-kinase family. 2001 J Bacteriol 183 292-300

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)