InterPro : IPR014606

Name  D,D-heptose 7-phosphate kinase Short Name  Heptose_7-P_kinase
Type  Family Description  This group of enzymes belongs to the GHMP kinase domain superfamily. GHMP kinases are a unique class of ATP-dependent enzymes (the abbreviation of which refers to the original members: galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase) []. Enzymes belonging to this superfamily contain three well-conserved motifs, the second of which has the typical sequence Pro-X-X-X-Gly-Leu-X-Ser-Ser-Ala and is involved in ATP binding []. The phosphate binding loop in GHMP kinases is distinct from the classical P-loops found in many ATP/GTP binding proteins. The bound ADP molecule adopts a rare syn conformation and is in the opposite orientation from those bound to the P-loop-containing proteins []. GHMP kinases display a distinctly bilobal appearance with their N-terminal subdomains dominated by a mixed beta-sheet flanked on one side by alpha-helices and their C-terminal subdomains containing a four stranded anti-parallel beta-sheet [, , , ].Aneurinibacillus thermoaerophilusprotein has been characterised as a D-glycero-D-manno-heptose 7-phosphate kinase that adds phosphate group to C-1 of D-glycero-D-manno-heptose 7-phosphate [], and has been called GmhB or HddA. Note that HddA is the preferred name for this protein because the name GmhB has also been used for the D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase, [, ]. This enzyme catalyses a step in the biosynthesis of the nucleotide-activated form GDP-D-glycero-D-manno-heptose []and is encoded by the heptose operon [].D-glycero-D-manno-heptose is a constituent of lipopolysaccharide (LPS) cores of Gram-negative bacteria, and also a component of the S-layer glycoprotein of the Gram-positive bacterium Aneurinibacillus thermoaerophilus. The principal architecture of S-layer glycoproteins resembles that of the LPS of Gram-negative bacteria and comparable pathways are used for the biosynthesis of these similar glycoconjugates [].WcbL of Burkholderia pseudomalleiis also involved in the synthesis of an LPS (type I O-polysaccharide moieties) [].LmbP is thought to belong to the lincomycin-production gene cluster of Streptomyces lincolnensis[].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

4 Contains

Id Name Short Name Type
IPR020568 Ribosomal protein S5 domain 2-type fold Ribosomal_S5_D2-typ_fold Domain
IPR013750 GHMP kinase, C-terminal domain GHMP_kinase_C_dom Domain
IPR006204 GHMP kinase N-terminal domain GHMP_kinase_N_dom Domain
IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup Ribosomal_S5_D2-typ_fold_subgr Domain

0 Found In

1 Parent Features

Id Name Short Name Type
IPR001174 Galactokinase/homoserine kinase Galkinase Family

10 Publications

First Author Title Year Journal Volume Pages
Peschke U Molecular characterization of the lincomycin-production gene cluster of Streptomyces lincolnensis 78-11. 1995 Mol Microbiol 16 1137-56
Zhou T Structure and mechanism of homoserine kinase: prototype for the GHMP kinase superfamily. 2000 Structure 8 1247-57
Wada T Crystal structure of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis. 2003 J Biol Chem 278 30022-7
Bork P Convergent evolution of similar enzymatic function on different protein folds: the hexokinase, ribokinase, and galactokinase families of sugar kinases. 1993 Protein Sci 2 31-40
Romanowski MJ Crystal structure of the Streptococcus pneumoniae phosphomevalonate kinase, a member of the GHMP kinase superfamily. 2002 Proteins 47 568-71
Thoden JB Molecular structure of galactokinase. 2003 J Biol Chem 278 33305-11
DeShazer D Identification of a Burkholderia mallei polysaccharide gene cluster by subtractive hybridization and demonstration that the encoded capsule is an essential virulence determinant. 2001 Microb Pathog 30 253-69
Schäffer C Surface-layer glycoproteins: an example for the diversity of bacterial glycosylation with promising impacts on nanobiotechnology. 2004 Glycobiology 14 31R-42R
Kneidinger B Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli. 2002 J Bacteriol 184 363-9
Kneidinger B Biosynthesis of nucleotide-activated D-glycero-D-manno-heptose. 2001 J Biol Chem 276 20935-44

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)