InterPro : IPR001174

Name  Galactokinase/homoserine kinase Short Name  Galkinase
Type  Family Description  The lincomycin (LM)-production gene cluster of an over-producing strain ofStreptomyces lincolnensishas been analysed []. The lmb/lmr gene cluster contains 27 open reading frames with putative biosynthetic orregulatory functions (lmb genes) and three resistance (lmr) genes []. Only a minority of the putative Lmb proteins belong to known proteinfamilies: these include members of the gamma-glutamyl transferases (LmbA);amino acid acylases (LmbC); aromatic amino acid aminotransferases (LmbF);imidazoleglycerolphosphate dehydratases (LmbK); dTDP-glucose synthases(LmbO); dTDP-glucose 4,6-dehydratases (LmbM); and (NDP-) ketohexose (or ketocyclitol) aminotransferases (LmbS) []. LmbP seems to show some similarity to a family of enzymes that share anN-terminal Gly/Ser-rich putative ATP-binding region: these include galacto-kinase (), homoserine kinase (), mevalonate kinase () and phosphomevalonate kinase[]. Sequence v031 from Mycobacterium tuberculosis[]is also a homologue.
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

1 Child Features

Id Name Short Name Type
IPR014606 D,D-heptose 7-phosphate kinase Heptose_7-P_kinase Family

4 Contains

Id Name Short Name Type
IPR020568 Ribosomal protein S5 domain 2-type fold Ribosomal_S5_D2-typ_fold Domain
IPR013750 GHMP kinase, C-terminal domain GHMP_kinase_C_dom Domain
IPR006204 GHMP kinase N-terminal domain GHMP_kinase_N_dom Domain
IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup Ribosomal_S5_D2-typ_fold_subgr Domain

0 Found In

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Tsay YH Cloning and characterization of ERG8, an essential gene of Saccharomyces cerevisiae that encodes phosphomevalonate kinase. 1991 Mol Cell Biol 11 620-31
Peschke U Molecular characterization of the lincomycin-production gene cluster of Streptomyces lincolnensis 78-11. 1995 Mol Microbiol 16 1137-56
Philipp WJ An integrated map of the genome of the tubercle bacillus, Mycobacterium tuberculosis H37Rv, and comparison with Mycobacterium leprae. 1996 Proc Natl Acad Sci U S A 93 3132-7



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)