InterPro : IPR017812

Name  Mycothiol ligase MshC Short Name  Mycothiol_ligase_MshC
Type  Family Description  This entry represents MshC, a l-cysteine:1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase enzyme that uses ATP to ligate a Cys residue to a mycothiol precursor molecule, in the second to last step in mycothiol biosynthesis []. This enzyme shows considerable homology to Cys--tRNA ligases, and many proteins are wrongly annotated as such. Mycothiol is found in Mycobacterium tuberculosis[], Corynebacterium glutamicum(Brevibacterium flavum), Streptomyces coelicolor, and various other members of the Actinobacteria. Mycothiol is an analog of glutathione.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

1 Contains

Id Name Short Name Type
IPR014729 Rossmann-like alpha/beta/alpha sandwich fold Rossmann-like_a/b/a_fold Domain

0 Found In

1 Parent Features

Id Name Short Name Type
IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase Cys-tRNA/MSH_ligase Family

2 Publications

First Author Title Year Journal Volume Pages
Newton GL A coupled spectrophotometric assay for l-cysteine:1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase and its application for inhibitor screening. 2006 Anal Biochem 353 167-73
Sareen D Mycothiol is essential for growth of Mycobacterium tuberculosis Erdman. 2003 J Bacteriol 185 6736-40

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)