InterPro : IPR026257

Name  FK506-binding protein Short Name  FK506_BP
Type  Family Description  FK506-binding proteins (FKBPs) are a particular class of peptidyl-prolyl cis-trans isomerases (PPIases). They are the intracellular receptors for two immunosuppressive compounds, rapamycin and FK506. PPIases are thought to act in conjunction with protein chaperones because they accelerate the rate of conformational interconversions around proline residues in polypeptides []. In Saccharomyces cerevisiae, FKBPs locate in nucleolus and interact with NOP53, which is is a novel nucleolar 60S ribosomal subunit biogenesis protein [].
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Sequence Features

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Proteins

InterPro protein domain ID --> Contigs

 

Other

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0 Found In

1 Parent Features

Id Name Short Name Type
IPR023566 Peptidyl-prolyl cis-trans isomerase, FKBP-type PPIase_FKBP Family

2 Publications

First Author Title Year Journal Volume Pages
Sydorskyy Y Nop53p is a novel nucleolar 60S ribosomal subunit biogenesis protein. 2005 Biochem J 388 819-26
Benton BM A novel FK506- and rapamycin-binding protein (FPR3 gene product) in the yeast Saccharomyces cerevisiae is a proline rotamase localized to the nucleolus. 1994 J Cell Biol 127 623-39



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)