InterPro : IPR001980

Name  Coenzyme A biosynthesis protein Short Name  LPS_biosynth
Type  Family Description  Temperature-sensitive mutants of Escherichia coli, defective in the transfer of 3-deoxy-D-manno-octulosonic acid (KDO) from CMP-KDO to a tetraacyldisaccharide 1,4'-bisphosphate precursor of lipid A, have been used to map KDO transferase activity on the E. coli chromosome []. The KDO transferase gene, designated kdtA, was shown to code for a 43kDa polypeptide. Overexpression of this single gene product greatly stimulates incorporation of two stereochemically distinct KDO residues during lipopolysaccharide biosynthesis in extracts of E. coli [].From these experiments this protein was thought to play a role in lipopolysaccharide biosynthesis, however now it is annotated as phosphopantetheine adenylyltransferase (), which catalyses the reversible transfer of an adenylyl group from ATP to 4'-phosphopantetheine to give dephospho-CoA (DPCOA) and pyrophosphate in the fourth (and penultimate) step of coenzyme A biosynthesis [].
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

1 Contains

Id Name Short Name Type
IPR004821 Cytidyltransferase-like domain Cyt_trans-like Domain

0 Found In

0 Parent Features

2 Publications

First Author Title Year Journal Volume Pages
Clementz T A gene coding for 3-deoxy-D-manno-octulosonic-acid transferase in Escherichia coli. Identification, mapping, cloning, and sequencing. 1991 J Biol Chem 266 9687-96
Geerlof A Purification and characterization of phosphopantetheine adenylyltransferase from Escherichia coli. 1999 J Biol Chem 274 27105-11



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)