InterPro : IPR003087

Name  Neutrophil gelatinase-associated lipocalin Short Name  N_gelatinase
Type  Family Description  Murine neutrophil gelatinase-associated lipocalin precursor (NGAL) exhibitsa 7-10-fold increase in expression in cultured mouse kidney cells infectedby Simian virus 40(SV40) or other viruses []. NGAL has been identified as a major secretory product of lipopolysaccharide-stimulated cultured mouse macrophages, suggesting that the protein might function in defence againstinfection []. Recently, NGAL has been shown to be identical to SIP24, a previously identified secretory product of quiescent mouse fibroblasts induced by serum, dexamethasone, basic fibroblast growth factor, and phorbolester []. Mouse plasma levels of NGAL rise as a result of increased expression levels in the liver, in response to intramuscular turpentine injection. Tumour necrosis factor can regulate NGAL expression in cultured liver cells. These findings indicate that NGAL is a positive acute phaseprotein and may possess immunosuppressive or anti-inflammatory properties, possibly linked to its regulation of neutrophil gelatinase or other plasmaprotein []. The uterus is also a major site of NGAL synthesis, especiallyat parturition, when expression increases significantly, suggesting aphysiological role for the protein in uterine secretions [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

1 Contains

Id Name Short Name Type
IPR022272 Lipocalin family conserved site Lipocalin_CS Conserved_site

0 Found In

1 Parent Features

Id Name Short Name Type
IPR002345 Lipocalin Lipocalin Family

5 Publications

First Author Title Year Journal Volume Pages
Liu Q Identification of a new acute phase protein. 1995 J Biol Chem 270 22565-70
Garay-Rojas E An apparent autocrine mechanism amplifies the dexamethasone- and retinoic acid-induced expression of mouse lipocalin-encoding gene 24p3. 1996 Gene 170 173-80
Meheus LA Identification by microsequencing of lipopolysaccharide-induced proteins secreted by mouse macrophages. 1993 J Immunol 151 1535-47
Kasik JW An increase in expression of the lipocalin 24p3 is found in mouse uterus coincident with birth. 1995 Am J Obstet Gynecol 173 613-7
Triebel S A 25 kDa alpha 2-microglobulin-related protein is a component of the 125 kDa form of human gelatinase. 1992 FEBS Lett 314 386-8

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)